Cialis

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What is Cialis?

Cialis is a medication used in the treatment of erectile dysfunction. The active ingredient is tadalafil, a selectively reversible inhibitor of phosphate phosphodiesterase of the 5 type, an enzyme that is found in the cavernous body, smooth muscles, other organs and parts of the human body. The drug relaxes smooth muscles, increases the flow of blood to the penis, as a result – an erection occurs.

It should be noted that tadalafil is effective only in the presence of sexual stimulation.

The effect of the medication occurs within 15 minutes (if there is sexual arousal) and lasts for 36 hours.

The active component does not adversely affect the organs of vision and does not affect the quality of sperm or the level of sex hormones.

How to take Cialis?

Of course, before you buy this drug from a Canadian pharmacy online, it makes sense to find out more about the drug itself, how it works and which dosage is right for you. Taking the right dose is the key to your success because taking less than necessary will not produce the effect desired while taking more can cause unpleasant adverse reactions that you’d rather avoid. The medication is most often prescribed at the dose of 10 mg tadalafil per pill. There are also 2.5 mg and 5 mg doses, but they are usually prescribed at the beginning of the treatment to see how the patient responds. Lower doses may also be more adequate for older patients, as this group of patients tends to be more sensitive to the effects of the active ingredient. 20 mg is prescribed if the patients that did not benefit to the extent expected from the 10 mg dose. The drug should be taken every time before sexual intercourse. Not taking the recommended dose of this medicine prior to sexual intercourse may result in weaker erections that will not last long enough for the patient to complete sexual intercourse. A pill should be taken about 45-60 minutes before having sex, as it takes some time for your body to react to the active ingredient and for an erection to occur.

Contraindications

The drug is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.

The drug is also contraindicated in the presence of the following diseases:

• myocardial infarction in the last 90 days;
• unstable angina or angina which occurs during sexual intercourse;
• heart failure (grade 2 or higher, according to the classification of the New York Heart Association) in the last 6 months;
• uncontrolled arrhythmias, hypotension (<90/50 mmHg) or uncontrolled hypertension;
• a stroke that occurred in the last 6 months.

The drug is contraindicated in patients with vision loss of one eye as a result of non-arterial anterior ischemic optic neuropathy, regardless of whether this was due to the previous effect of PDE-5 inhibitors or not.

The simultaneous use of PDE-5 inhibitors, including tadalafil, with guanylate cyclase stimulants is contraindicated since this could potentially lead to symptomatic hypotension.

The drug is not used in pediatrics.

Side effects

Cialis rarely causes hypersensitivity reactions, but the side effects are dose-dependent. In particular, it can cause such side effects (usually – short-term), such as:

• headache, dyspepsia, back pain, myalgia;
• allergic reactions – angioedema, allergic urticaria, rash, itching;
• dizziness, violation of cerebral circulation, loss of consciousness, transient ischemic attack, migraine, convulsions, passing amnesia;
• visual impairment, eyelid edema, conjunctiva hyperemia, optic neuropathy, retinal vein occlusion;
• hearing loss, hearing loss;
• tachycardia, myocardial infarction, stenocardia, ventricular arrhythmia, hot flashes, arterial hypotension, arterial hypertension;
• rhinitis, shortness of breath, epistaxis;
• dyspepsia, gastroesophageal reflux;
• rash, hyperhidrosis;
• myalgia;
• hematuria;
• bleeding from the penis, hemospermia, prolonged erection, priapism;
• chest pain, swelling of the face.

Pregnancy and breastfeeding

The drug is not intended for use in women.

Interactions

You should inform your doctor about all the drugs you are taking. Cialis tablets may interact with certain medications and can be taken with other medicines only if recommended by a doctor.

• Never combine these ED tablets with cGMP specific PDE type-5 inhibitors/nitrates, PDE inhibitors/Riociguat;
• Caution should be taken when using tadalafil preparations with sildenafil; tadalafil, strong cyp3a4 inhibitors, alpha-blockers, HIV protease inhibitors, cobicistat, vardenafil/boceprevir, telaprevir, antihypertensives/tizanidine.

Precautions

An overdose of tadalafil can cause an increase in adverse reactions. In case of overdose, standard symptomatic therapy is recommended – gastric lavage and enterosorbent administration. Hemodialysis does not significantly affect the excretion of the drug.

If you experience priapism (an erection lasting 4 hours or more) after taking PDE-5 inhibitors, yo u need to immediately seek medical help. Late treatment of priapism leads to damage to the tissues of the penis, which can result in irreversible impotence.

Studies show that moderate doses of alcohol cause no significant changes in the body. However, the use of ethanol at maximum doses causes negative reactions. It’s recommended that patients give up alcohol at the time of treatment with PDE-5 inhibitors and strictly monitor their lifestyle.

Sexual activity has a potential risk for patients with cardiovascular disease. Therefore, men with heart diseases who are contraindicated sexual activity should not use these pills.

The safety and efficacy of this drug in combination with other ED pills have not been studied.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor reactions.

The effectiveness of the drug in patients who have undergone surgery on the pelvic organs or radical neuro-sparing prostatectomy is unknown.

The shelf life is indicated on the package. Do not exceed storage periods.

Storage temperature should not exceed 25° C. Temperature deviations can change the properties of the drug, so it should always be stored in its original packaging.

Buying Cialis online

Is it worth it to buy Cialis at Canada pharmacy or should you just go the usual way and see your doctor in advance, getting a prescription and making all those other steps that follow? More and more people learn from their own experience that it’s a lot more advantageous to find a reliable online drug supplier that would be able to offer best-quality ED pills at a reasonable price. The reason why you may also want to get your ED pills from Canadian pharmacy may not be the same as that of other people, because everyone has their own. Some may want to avoid spending too much of their time making appointments and getting a prescription, especially if they are not covered for erectile dysfunction. Others want a much lower price, which is what online pharmacies are famous for. Other people would like to enjoy the convenience of ordering any drugs they need from their home, without any need to go anywhere and feel embarrassed when they meet someone they know at the local pharmacy when buying pills for erectile dysfunction. So, buying this drug at Canada pharmacy online is a great way for different people to achieve the one goal they all have in common: durable and harder erections that were impossible because of erectile dysfunction. Which one of those is yours does not matter as long as you know how to order Cialis from Canadian pharmacy quickly and without having to doubt your decision. Once you have a place like that, you can come back any time and place an order for any amount of the drug required, so your erectile dysfunction is not going to be a problem anymore.